Inhibition of the RNA-dependent RNA Polymerase of the SARS-CoV-2 by Short Peptide Inhibitors짧은 펩티드 억제제에 의한 SARS-CoV-2의 RNA 의존성 RNA 중합효소 억제Article Published on 2021-12-012022-09-11 Journal: European journal of pharmaceutical sciences : offi [Category] SARS, 치료제, [키워드] activities activity antiviral agent Antiviral agents approach Arg2 binding site comparison complexes COVID-19 patient COVID-19. detrimental docking Docking studies drug drugs early recovery help inhibiting inhibition inhibitor inhibitors insertion insertion site molecular docking NTP nucleotide nucleotides patients peptide Peptide inhibitor Peptide Inhibitors peptides proliferation RdRP Remdesivir Replication RNA RNA-dependent RNA polymerase SARS-CoV-2 synthesis the SARS-CoV-2 viral genome Viral load viral loads [DOI] 10.1016/j.ejps.2021.106012 PMC 바로가기 [Article Type] Article
Furin cleavage of the SARS-CoV-2 spike is modulated by O -glycosylationSARS-COV-2 스파이크의 푸린 절단은 O- 글리코 실화에 의해 조절된다.407 Published on 2021-11-032022-08-13 Journal: Proceedings of the National Academy of Sciences of [Category] Biochemistry, COVID-19, SARS, [키워드] O- abrogate Alpha alpha and delta variants Amino acid amino acids cells circumvent cleavage coronavirus decrease delta variant Delta variants dependent on expressed family members furin furin cleavage furin cleavage of S furin cleavage site GALNT GALNT enzyme global pandemic glycosylating S glycosylation highlight host O -glycosylation host-mediated O -glycosylation human respiratory cell human respiratory cells increase insertion insertion site modulated modulating Mutation O -glycosylation P681 P681 mutation P681 mutations position position 681 proline pseudoviral infectivity respiratory responsible resulting SARS-CoV-2 coronavirus SARS-COV-2 infection shown Significance spike Spike protein syncytia formation target targets the SARS-CoV-2 the spike protein tropism unique Viral viral infectivity viral infectivity/tropism [DOI] 10.1073/pnas.2109905118 PMC 바로가기 [Article Type] 407
Identification of four insertion sites for foreign genes in a pseudorabies virus vectorResearch Published on 2021-05-122022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] Affect antibody BAC Bacterial bacterial artificial chromosome Cell chromosome epidemic diarrhea exhibited expression expression cassette Gene Expression Genome growth identification immunofluorescence insertion insertion site mRNA expression mutant Noncoding region parental PCR post infection Pseudorabies virus Pseudoraby Real-time PCR recovered Result S gene Safe shown spike gene Vaccine Vaccines variant virulent virus virus virus strain Virus vector [DOI] 10.1186/s12917-021-02887-w PMC 바로가기 [Article Type] Research